Toxins

2022-09-12 05:06| 来源: 网络整理| 查看: 265

Next Article in Journal Zearalenone Promotes Cell Proliferation or Causes Cell Death? Next Article in Special Issue Saccharomyces cerevisiae Boulardii Reduces the Deoxynivalenol-Induced Alteration of the Intestinal Transcriptome Previous Article in Journal Why is Skeletal Muscle Regeneration Impaired after Myonecrosis Induced by Viperid Snake Venoms? Previous Article in Special Issue The Effects of Deoxynivalenol and Zearalenone on the Pig Large Intestine. A Light and Electron Microscopy Study Journals Topics Information For Authors For Reviewers For Editors For Librarians For Publishers For Societies For Conference Organizers Open Access Policy Institutional Open Access Program Special Issues Guidelines Editorial Process Research and Publication Ethics Article Processing Charges Awards Testimonials Author Services Initiatives Sciforum MDPI Books Preprints Scilit SciProfiles Encyclopedia JAMS Proceedings Series About Overview Contact Careers News Blog Sign In / Sign Up Notice clear Notice

You are accessing a machine-readable page. In order to be human-readable, please install an RSS reader.

Continue Cancel clear

All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited.

Feature Papers represent the most advanced research with significant potential for high impact in the field. Feature Papers are submitted upon individual invitation or recommendation by the scientific editors and undergo peer review prior to publication.

The Feature Paper can be either an original research article, a substantial novel research study that often involves several techniques or approaches, or a comprehensive review paper with concise and precise updates on the latest progress in the field that systematically reviews the most exciting advances in scientific literature. This type of paper provides an outlook on future directions of research or possible applications.

Editor鈥檚 Choice articles are based on recommendations by the scientific editors of MDPI journals from around the world. Editors select a small number of articles recently published in the journal that they believe will be particularly interesting to authors, or important in this field. The aim is to provide a snapshot of some of the most exciting work published in the various research areas of the journal.

Journals Topics Information For Authors For Reviewers For Editors For Librarians For Publishers For Societies For Conference Organizers Open Access Policy Institutional Open Access Program Special Issues Guidelines Editorial Process Research and Publication Ethics Article Processing Charges Awards Testimonials Author Services Initiatives Sciforum MDPI Books Preprints Scilit SciProfiles Encyclopedia JAMS Proceedings Series About Overview Contact Careers News Blog Sign In / Sign Up Submit Journals Toxins Volume 10 Issue 5 10.3390/toxins10050183

Submit to this Journal Review for this Journal Edit a Special Issue ► ▼ Article Menu Article Menu Article Overview Abstract Open Access and Permissions Share and Cite Article Metrics Order Article Reprints Article Versions Abstract Article Versions Notes Full-Text HTML Full-Text PDF Full-Text PDF With Cover Full-Text XML Full-Text Epub Related Info Links Google Scholar More by Authors Links on DOAJ Maruo, V. Mayumi Bracarense, A. Paula Metayer, J. Vilarino, M. Oswald, I. P. Pinton, P. on Google Scholar Maruo, V. Mayumi Bracarense, A. Paula Metayer, J. Vilarino, M. Oswald, I. P. Pinton, P. on PubMed Maruo, V. Mayumi Bracarense, A. Paula Metayer, J. Vilarino, M. Oswald, I. P. Pinton, P. /ajax/scifeed/subscribe Abstract Views Full-Text Views Citations - Altmetrics Printed Edition A printed edition of this Special Issue is available at MDPI Books.... Book cover image

share announcement question_answer thumb_up ... textsms ... Need Help? Support

Find support for a specific problem in the support section of our website.

Get Support Feedback

Please let us know what you think of our products and services.

Give Feedback Information

Visit our dedicated information section to learn more about MDPI.

Get Information clear JSmol Viewer clear Open AccessFeature PaperArticle Ergot Alkaloids at Doses Close to EU Regulatory Limits Induce Alterations of the Liver and Intestine by

Viviane Mayumi Maruo 1,4,

Ana Paula Bracarense 2 ORCID

Jean-Paul Metayer 3,

Maria Vilarino 3 ORCID

Isabelle P. Oswald 4,* ORCID

and

Philippe Pinton 4 ORCID

1 Universidade Federal do Tocantins, Aragua铆na 77824-838, Brazil 2 Laboratory of Animal Pathology, Universidade Estadual de Londrina, Londrina 86057-970, Brazil 3 ARVALIS-Institut du V茅g茅tal, Station exp茅rimentale, 41100 Villerable, France 4 Toxalim (Research Centre in Food Toxicology), Universit茅 de Toulouse, INRA, ENVT, INP-Purpan, UPS, 31027 Toulouse, France * Author to whom correspondence should be addressed. Toxins 2018, 10(5), 183; https://doi.org/10.3390/toxins10050183 Received: 21 March 2018 / Revised: 7 April 2018 / Accepted: 17 April 2018 / Published: 1 May 2018 (This article belongs to the Special Issue Effects of Mycotoxins on the Intestine) View Full-Text Download PDF Browse Figures Citation Export BibTeX EndNote RIS Cite This Paper Abstract An increase in the occurrence of ergot alkaloids (EAs) contamination has been observed in North America and Europe in recent years. These toxins are well known for their effects on the circulatory and nervous systems. The aim of this study was to investigate the effect of EAs on the liver and on the intestine using the pig both as a target species and as a non-rodent model for human. Three groups of 24 weaned piglets were exposed for 28 days to control feed or feed contaminated with 1.2 or 2.5 g of sclerotia/kg, i.e., at doses close to EU regulatory limits. Contaminated diets significantly reduced feed intake and consequently growth performance. In the liver, alteration of the tissue, including development of inflammatory infiltrates, vacuolization, apoptosis and necrosis of hepatocytes as well as presence of enlarged hepatocytes (megalocytes) were observed. In the jejunum, EAs reduced villi height and increased damage to the epithelium, reduced the number of mucus-producing cells and upregulated mRNA coding for different tight junction proteins such as claudins 3 and 4. In conclusion, in term of animal health, our data indicate that feed contaminated at the regulatory limits induces lesions in liver and intestine suggesting that this limit should be lowered for pigs. In term of human health, we establish a lowest observed adverse effect level (LOAEL) of 100 μg/kg body weight (bw) per day, lower than the benchmark dose limit (BMDL) retained by European Food Safety Authority (EFSA) to set the tolerable daily intake, suggesting also that regulatory limit should be revised. View Full-Text Keywords: Claviceps; liver; digestive tract; mycotoxin; sclerotia; ergot alkaloids; toxicity Claviceps; liver; digestive tract; mycotoxin; sclerotia; ergot alkaloids; toxicity ►▼ Show Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. SciFeed

Share and Cite MDPI and ACS Style

Maruo, V.M.; Bracarense, A.P.; Metayer, J.-P.; Vilarino, M.; Oswald, I.P.; Pinton, P. Ergot Alkaloids at Doses Close to EU Regulatory Limits Induce Alterations of the Liver and Intestine. Toxins 2018, 10, 183. https://doi.org/10.3390/toxins10050183

AMA Style

Maruo VM, Bracarense AP, Metayer J-P, Vilarino M, Oswald IP, Pinton P. Ergot Alkaloids at Doses Close to EU Regulatory Limits Induce Alterations of the Liver and Intestine. Toxins. 2018; 10(5):183. https://doi.org/10.3390/toxins10050183

Chicago/Turabian Style

Maruo, Viviane Mayumi, Ana Paula Bracarense, Jean-Paul Metayer, Maria Vilarino, Isabelle P. Oswald, and Philippe Pinton. 2018. "Ergot Alkaloids at Doses Close to EU Regulatory Limits Induce Alterations of the Liver and Intestine" Toxins 10, no. 5: 183. https://doi.org/10.3390/toxins10050183

Find Other Styles Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here. Article Metrics No No Article Access Statistics For more information on the journal statistics, click here. Multiple requests from the same IP address are counted as one view. Abstract views Pdf views Html views Article Access Map by Country/Region 1 Zoom | Orient | As Lines | As Sticks | As Cartoon | As Surface | Previous Scene | Next Scene Toxins, EISSN 2072-6651, Published by MDPI Disclaimer The statements, opinions and data contained in the journal Toxins are solely those of the individual authors and contributors and not of the publisher and the editor(s). MDPI stays neutral with regard to jurisdictional claims in published maps and institutional affiliations. RSS Content Alert Further Information Article Processing Charges Pay an Invoice Open Access Policy Contact MDPI Jobs at MDPI Guidelines For Authors For Reviewers For Editors For Librarians For Publishers For Societies For Conference Organizers MDPI Initiatives Sciforum MDPI Books Preprints Scilit SciProfiles Encyclopedia JAMS Proceedings Series Follow MDPI LinkedIn Facebook Twitter

漏 1996-2022 MDPI (Basel, Switzerland) unless otherwise stated Disclaimer The statements, opinions and data contained in the journals are solely those of the individual authors and contributors and not of the publisher and the editor(s). MDPI stays neutral with regard to jurisdictional claims in published maps and institutional affiliations. Terms and Conditions Privacy Policy We use cookies on our website to ensure you get the best experience. Read more about our cookies here. Accept We have just recently launched a new version of our website. Help us to further improve by taking part in this short 5 minute survey here. here. Never show this again Share Link Copy clear Share https://www.mdpi.com/287978 clear Back to TopTop

【本文地址】

公司简介

联系我们